Patients with lips blistering, swelling, according to the different causes of swelling, clinical treatment can take different methods: First, if the herpes simplex virus infection caused by herpes, can be through the antiviral treatment, such as external application of Aloxivir ointment, intravenous application of ribavirin injection, often can achieve better therapeutic effect. Second, if the patient’s mouth is obviously swollen after contact with allergens, then the patient needs to avoid contact with allergens as soon as possible, and at the same time, oral loratadine and other anti-allergy drugs, which can reduce the allergic perversion in the body and alleviate the symptoms of swelling of the mouth. Third, if the patient’s lips are accompanied by swelling and cyst formation, there may be mucous gland cysts, this time the need for surgical excision of mucous glands, to avoid the cysts progressive enlargement. At the same time, we should keep the mouth clean, avoid oral ulcers or infections, resulting in repeated episodes of mouth swelling and blisters.