1. Therapeutic principle High intensity focused ultrasound (HIFU) is commonly known as “ultrasonic knife”. Its principle is to use ultrasonic waves can penetrate soft tissues and can be focused on the physical characteristics of the multiple beams of ultrasound outside the body using the principle of concave lens focused on the body of the tumor foci, so that the tumor cells in an instant to reach the temperature of 700C – 1000C, causing the tumor target tissues to undergo coagulative necrosis, and the surrounding tissues are rarely or not damaged, so as to achieve the purpose of “burned to death” tumor cells. This will cause the tumor target tissue to undergo coagulative necrosis with little or no damage to the surrounding tissues, thus achieving the purpose of “burning” the tumor cells. Indications of “Ultrasonic Knife” treatment It is mainly applicable to the treatment of pancreatic cancer, primary and secondary liver cancer, kidney cancer, bladder cancer, prostate cancer, ovarian cancer, abdominal metastatic cancer and so on. For benign diseases, such as prostate hypertrophy, uterine fibroids and so on, it also has better curative effect. 3, “ultrasonic knife” treatment advantages “ultrasonic knife” and conventional radiotherapy, chemotherapy, surgery, etc. Compared with the following advantages: ① no surgery, no bleeding, no trauma, no anesthesia, little pain, no infection, etc.; ② no nausea, vomiting, hair loss, fatigue, anorexia, leukocyte decline, immune system decline, etc. No side effects such as nausea, vomiting, hair loss, fatigue, anorexia, decrease in white blood cells, decrease in immunity, etc.; ③ For middle and advanced tumors, in addition to killing the primary tumor cells locally, it can be combined with radiotherapy and chemotherapy to improve the therapeutic effect of radiotherapy and chemotherapy. For tumors that cannot be removed by surgery, are not sensitive to radiotherapy or chemotherapy, or are unwilling to undergo surgical resection again for postoperative recurrence, ultrasonic knife can shrink or necrolyze the tumor entity, which is conducive to alleviating the symptoms, improving the patient’s general condition, and improving the muscle immunity and the patient’s quality of life. For the old and weak, or patients with obvious complications of other organs (such as liver, kidney, pancreas, etc.) and other obvious contraindications to surgery, it can also be performed; ④ easy operation, precise positioning, safe treatment, without affecting the patient’s normal work and life; ⑤ ultrasonic knife is a mechanical wave, which is free of radiation pollution to the doctor and the environment, and is known as the most effective and efficient way to treat tumors. (5) “Ultrasonic knife” is a mechanical wave, no radiation pollution to the doctor and the environment, known as the “green therapy”. Contraindications of HIFU treatment 4. Contraindications of “ultrasonic knife” treatment: ① ultrasound incidence channel is blocked by bones or air-containing tissues, such as lungs, mediastinum, esophagus and other tumors that can not be treated; ② the distance between the target skin and the target skin is less than 1cm, or there are ulcers or infections at the skin at the incidence channel or heavy radioactive dermatitis; ③ inferior vena cava, renal vein cancerous thrombus before placing the filter; ⑤ ultrasonic knife is a kind of mechanical wave, which has no radiation pollution to doctors and the environment. Cancer thrombus of inferior vena cava, renal vein before placing the filter or removing the thrombus by surgery; ④ platelets less than 30×109 /L and serious disorders of the coagulation system; ⑤ serious insufficiency of liver, kidney, heart, lung and brain functions; ⑥ advanced tumor patients with 60 points of KPS; ⑦ a large amount of ascites and serious jaundice (except for jaundice lifting); ⑧ heat allergy; ⑨ children under 4 years old and psychiatric patients.