Frequent hiccups after dexamethasone injection can be relieved by reducing the dosage or stopping the medication as prescribed by the doctor. Dexamethasone belongs to the adrenocorticotropic hormone class of drugs. When this product is used, some adverse reactions may occur, such as concurrent infections and gastrointestinal irritation (nausea, vomiting, hiccups). After use, if the user experiences frequent hiccups, the dosage may be reduced or discontinued at the discretion of the physician after evaluation. On this basis, hot water bag should be placed on the abdomen to accelerate local blood circulation and relieve symptoms, or oral domperidone or mosapride should be taken to improve symptoms. Due to individual differences, the specific solution will depend on the patient’s condition. In addition, frequent hiccups may be caused by other factors, it is recommended that patients go to the hospital in a timely manner, and follow the doctor’s instructions to standardize the use of medication.