High gamma-glutamyl transpeptidase may be caused by non-disease factors, biliary tract diseases, liver diseases and so on. 1. Non-disease factors: frequent consumption of alcohol, staying up late or taking certain drugs (such as phenobarbital) can cause high gamma-glutamyl transpeptidase. 2. Biliary tract diseases: such as gallstones, cholecystitis, cholangitis, etc. can appear high γ-glutamyl transpeptidase, usually accompanied by biliary colic and other symptoms, and some patients do not have obvious symptoms. 3. Liver diseases: such as alcoholic hepatitis, viral hepatitis, cirrhosis, hepatocellular carcinoma, etc. can cause damage to liver cells, resulting in abnormal liver function and high γ-glutamyl transpeptidase. There are many reasons for high gamma-glutamyl transpeptidase, so it is recommended to consult a doctor in time to find out the cause of the disease under the guidance of a professional doctor and treat it as soon as possible.