Milled glass nodules that are small in size and do not cause localized burr sign and pleural invasion, and are more stable through regular review of this condition, do not require excessive treatment, and can be observed through regular review of thin-layer CT to observe the changes of the milled glass nodules. If the patient has an ill-defined ground-glass nodule, accompanied by burr sign and pleural invasion, the nodule volume gradually increases through the process of regular review. In this case, the risk of cancerous transformation of the nodule is significantly increased, and it is recommended that the patient undergoes timely surgical removal of the localized nodule. Based on the results of postoperative examination, if the nodule is a malignant tumor, chemotherapy, targeted therapy and other comprehensive treatments can be carried out to prolong the patient’s life as much as possible, improve the cure rate, and avoid premature recurrence of tumor cells.