The time needed to cure Gram-negative diplococcus bacteria is related to the specific condition of the patient, for example, meningitis diplococcal infection may need about two weeks of treatment; gonococcal infection caused by urethritis, it may take 1~2 weeks, but the specific time of treatment should also be combined with the condition of the recovery. 1. Meningococcal infection may cause meningitis, which may be life-threatening in severe cases and requires active treatment. In general, meningitis caused by meningococcus may be cured after about two weeks of treatment. 2. Gonococcus, also a gram-negative diplococcus, mainly causes genitourinary infections, such as urethritis. Urethritis caused by gonococcus may recover in 1~2 weeks after active anti-infection treatment. Whether meningococcal or gonococcal infections, the time required for cure is variable and needs to be judged in conjunction with the patient’s response to treatment, and some patients may even have progressive disease, leading to serious comorbidities that need to be actively addressed.