Azelaic acid is commonly used clinically in the form of cream, the main side effects are skin irritation symptoms, some patients may experience dry skin, erythema, flaking, contact dermatitis and other adverse reactions. Side effects of azelaic acid cream are generally mild and transient, some patients can appear local itching, burning, stinging and other skin irritation symptoms, other adverse reactions include dry skin, flaking, dermatitis, erythema, etc., the total incidence of less than 1%, and a very small number of patients can appear after the use of drugs, such as leukoplakia, hirsutism, redness, asthma aggravation and other side effects. It should be noted that the use of azelaic acid cream is prohibited for those who are allergic to any component of the drug, and the site of application should not be used as a closed bandage. Patients should follow the doctor’s instructions to use the drug, if serious discomfort occurs during the use of the drug, the drug should be stopped immediately, if necessary, consult a doctor.