There are many causes of knee pain, and the specific treatment needs to be tailored to the cause of the knee pain in order to treat the patient aggressively. For example, if the knee pain is caused by an infection, it is necessary to actively control the infection with early antibiotics. If the knee pain is due to gout, oral colchicine, avoidance of soy foods, seafood and beer, and animal offal are required. If the knee pain is caused by osteoarthritis, it is necessary to reduce the amount of exercise at an early stage, apply local heat or scalding, take oral non-steroidal anti-inflammatory and analgesic drugs and cartilage nourishing drugs, such as Nimesulide capsules and glucosamine hydrochloride, but if the joint has become deformed and seriously affects the normal function of the patient, it is necessary to actively perform artificial total knee replacement surgery. However, in cases where the joint has become deformed and is seriously affecting the patient’s function, active total knee replacement surgery is necessary.