1, osteoarthritis non-pharmacological treatment including patient health education, self-training, weight loss, aerobics, joint mobility training, muscle training, the use of mobility aids, wedge walking insoles for internal knee roll, occupational therapy and joint protection, daily life aids and so on. A significant portion of patients in Europe and the United States can reduce their symptoms and return to normal life and work through the above treatments. China’s investment in this area and the perception of health care professionals is still weak, and strengthening this work in the future is something that medical professionals at all levels should pay attention to. Patients with osteoarthritis of the knee often present with reduced quadriceps muscle strength, which was previously thought to be caused by disuse atrophy, but recent studies abroad have concluded that quadriceps muscle atrophy is not entirely caused by osteoarthritis, and that reduced quadriceps muscle strength may be one of the risk factors for osteoarthritis of the knee. The cushioning capacity is reduced, so strengthening quadriceps muscle strength training and aerobic training is beneficial to patients with osteoarthritis. 2, osteoarthritis drug treatment (1) sodium hyaluronate: the main component of the synovial fluid of the joint cavity, one of the components of the cartilage matrix, plays a lubricating role in the joint, reducing friction between tissues, joint cavity injection can significantly improve the inflammatory response of synovial tissue, enhance the viscosity and lubrication function of the joint fluid, protect the articular cartilage, promote the healing and regeneration of articular cartilage, relieve pain and increase the mobility of the joint. Mobility. It is often injected intra-articularly, 25mg once, once a week for 5 weeks, with strict aseptic operation. (2) Glucosamine: It is the most important monosaccharide of polyglucosamine (GS) and proteoglycan in the matrix of articular cartilage. In normal people, GS can be synthesized by amination of glucose, but in osteoarthritis, the synthesis of GS in chondrocytes is blocked or insufficient, resulting in softening of cartilage matrix and loss of elasticity, destruction of collagen fiber structure, and increase of cartilage surface lumen, causing bone wear and destruction. Glucosamine can block the pathogenesis of osteoarthritis, promote the synthesis of proteoglycans with normal structure in chondrocytes, and inhibit the production of enzymes (such as collagenase and phospholipase A2) that damage tissue and cartilage, reduce damage to chondrocytes, improve joint movement, relieve joint pain, and delay the course of osteoarthritis. It is best taken orally 250-500mg once, 3 times a day, with meals. (3) Non-steroidal analgesic anti-inflammatory drugs: can inhibit the synthesis of cyclooxygenase and prostaglandin, counteract the inflammatory response, and relieve joint edema and pain. You can use ibuprofen 200-400mg once, 3 times a day; or aminoglycoside zinc 200mg once, 3 times a day; nimesulide 100mg once, 2 times a day for 4-6 weeks. 3.Surgical treatment of osteoarthritis If the symptoms of osteoarthritis are very serious, drug treatment is ineffective, and affects the patient’s daily life, surgical intervention should be considered. (1) For osteoarthritis of the knee joint, some people advocate arthroscopic arthroscopic debridement first. This type of surgery is effective for some patients in the near future and can significantly improve symptoms, but the long-term effect is not certain. (2) Joint replacement surgery is effective in relieving pain and restoring joint function in most patients with osteoarthritis, femoral head necrosis, and rheumatoid arthritis, but there are certain immediate and long-term complications of joint replacement surgery, such as loosening and wear of components and osteolysis, which cannot be completely resolved at present. Therefore, it is important to strictly control the surgical indications for joint replacement. Strictly speaking, the indications for surgery include: (i) radiological evidence of joint damage; (ii) the presence of moderate to severe persistent pain or disability; and (iii) patients who have failed to respond to various non-surgical treatments.