Stomach discomfort and heartburn may be reflux esophagitis, gastric diseases, usually can not be self-healing, need to be on the cause of conservative treatment or surgical treatment. 1. For reflux esophagitis, it is necessary to follow the doctor’s advice to take oral domperidone and other gastric stimulants, omeprazole and other proton pump inhibitors; if the effect of drug treatment is not obvious, you can choose anti-reflux surgery. 2. For gastric diseases, such as chronic gastritis, oral administration of mucosal protective agents such as aluminum thioglycollate, proton pump inhibitors such as omeprazole, and gastric stimulants such as domperidone can be prescribed; if combined with Helicobacter pylori infection, quadruple therapy is required, i.e., one type of proton pump inhibitor (such as omeprazole) + two types of antibiotics (metronidazole, clarithromycin, etc.) + one type of bismuth agent (bismuth potassium citrate, etc.). Peptic ulcer can follow the doctor’s prescription oral omeprazole and other acid inhibitors, magnesium aluminum carbonate and other mucosal protective agents; if the combination of Helicobacter pylori infection, the application of quadruple therapy treatment; if the complication of a large number of bleeding, acute perforation and other serious conditions, need to be operated on surgically. It is recommended that people who feel heartburn in the stomach go to the hospital in time, clarify the cause of the disease, standardized treatment under the guidance of the doctor, and do not blindly wait for self-cure, so as not to delay the condition.