Painful leg pressure can be caused by a variety of factors, such as over-exercise and other lifestyle factors, as well as diseases such as salpingitis and deep vein thrombosis. 1. Excessive exercise: when excessive running and other sports exceed the limit of aerobic exercise, it may cause the body metabolism to produce a large amount of lactic acid, which leads to leg pressure soreness. 2. Danovirus: it is an acute non-purulent skin disease, which can be caused by bacterial infection, alcoholism and other factors. The main symptoms are burning sensation and tenderness in the calf, which may be accompanied by fever and headache. 3. Deep vein thrombosis: it is a kind of venous reflux disorder, which can be caused by trauma, prolonged bed rest and other factors. The main symptoms can be seen as pressure pain at the back of the calf or inner thigh, aggravated by activities, etc.. If the leg pressure pain, you should go to the hospital in time, hospital-related examination to clarify the cause of the disease, and actively cooperate with the doctor’s treatment.