Knee pain needs to identify the cause to eradicate, may be physiological, may also be pathological, such as synovitis, meniscus injury, etc.; physiological reasons need to adjust the lifestyle, pathologically induced need to be under the guidance of the doctor to carry out targeted treatment, such as medication, surgical treatment. 1. Physiological: knee pain caused by wear and tear due to sports, mostly occurs in people who like to run more, usually more knee movement, cartilage wear and tear will be more serious. You need to reduce the frequency of running and pay attention to rest. 2. Pathologic (1) Synovitis, related to excessive joint movement, joint injury, cartilage degeneration and osteophytes, manifested as swelling and pain in the knee joint. The pain can be reduced or relieved by celecoxib and bisacodyl; if necessary, arthroscopic synovectomy, osteotomy, joint fusion and arthroplasty can be performed. (2) Meniscus injury refers to the meniscus rupture caused by rotational force, extrusion, meniscus disease and other factors, manifested as severe pain, inability to straighten the knee joint, swelling and so on. At present, there is no specific drug; if necessary, total meniscectomy, partial meniscectomy, meniscus repair. Knee pain is a very common symptom in life, and it is not excluded to be caused by advance factors. When the pain is obvious, if the adjustment of lifestyle is not obvious, we should go to the hospital in time to clarify the cause of the disease, and follow the doctor’s instructions to standardize the treatment.