Ultrasound report of thyroid nodule, free thyroxine 22.5pmol/L is within normal range, if benign and asymptomatic thyroid nodule can be reviewed regularly, malignant or thyroid nodule with compression symptoms need surgery. The normal range of free thyroxine is 11.5~22.7 pmol/L, so the free thyroxine of 22.5 pmol/L belongs to the normal range; in addition, the ultrasound report suggests that there is a thyroid nodule, and it is necessary to combine with the specific performance of the ultrasound, such as the edge of the edge is clear, whether the morphology is regular, whether there is a point of clusters of calcification and other performances to make a preliminary judgment of the benign or suspected malignancy. If the biopsy shows benign thyroid nodules with no obvious clinical signs, the patient can undergo regular checkups and no special treatment is needed. If the thyroid nodules are malignant or benign, but the nodules are large enough to cause pressure symptoms, surgical resection should be considered. If there is an ultrasound report of thyroid nodule with free thyroxine 22.5 pmol/L, it is recommended to go to the hospital and ask the doctor to make a judgment and give a treatment plan.