Yue Ju Wan, also known as Ligusticum Rhizoma Pill, is a representative formula for the treatment of depression, which has the effect of regulating qi and relieving depression. It first appeared in “Danxi Xinfa ? Volume 3? Six Yu 52: “Yue Ju Wan is used to relieve all depressions.” The formula is composed of five herbs: Atractylodes, Rhizoma Atractylodes, Rhizoma Chuanxiong, Rhizoma Shenqu, and Gardenia, and is used to treat the six depressions of Qi, blood, phlegm, fire, dampness, and food, which can be seen clinically as chest and diaphragmatic congestion, abdominal congestion, acid swallowing and vomiting, dietary failure, chest and abdominal tingling, belching and abdominal distention. “In the formula, Xiang Shen Hui is the ruling medicine to regulate qi and relieve pain, treating qi depression; Chuan Xiong is the qi medicine in the blood, opening up depression and treating blood depression; Gardenia diarrhea fire and remove annoyance, treating fire depression; Shen Qu eliminates food and stomach, treating food depression; Cang Zhu dries dampness and strengthens the spleen, removing phlegm and damp depression; all the medicines together, playing the effect of moving qi and relieving all depression. The influence of Yue Ju Wan is so far-reaching that later generations of physicians have created new formulas by taking the meaning of its formula, or extended its application by adding or subtracting variations. The occurrence and development of many diseases are associated with the six depressions of qi, blood, phlegm, fire, dampness, and food, as Wang Cui of the Ming Dynasty said: “The onset of disease is mostly due to depression” (Medical Scripture Retrospective Collection? Wu Cheng of the Qing dynasty said bluntly, “All diseases are born of depression, so all diseases of depression are often eight to nine out of ten” (Buju Ji? Volume 18? Seven emotions within the depression”). Therefore, from its formula, Yue Ju Wan has a wide and complex clinical application. As mentioned above, Yueju Pill can be used for various internal diseases, gynecological diseases and miscellaneous diseases through appropriate additions and subtractions. According to the physiological function of the spleen rising and stomach descending, the former people concluded that the spleen and stomach are the pivot of the qi of the middle jiao, and the function of the middle jiao is to carry the upper and lower, and to transport the essence of water and grain, so the spleen and stomach of the middle jiao is considered to be the root of the posterior nature of the human body. The disease of spleen and stomach may be caused by dietary stagnation and qi stagnation; or by internal obstruction of phlegm and dampness and damp-heat obstruction; or by weakness of spleen and stomach and loss of elevation; or by stagnation of blood stasis; or by liver stagnation and qi stagnation and transgression of the spleen and stomach; the etiology of spleen and stomach disease is closely related to the six depressions of qi, blood, phlegm, fire, dampness and food. This formula involves the liver and the spleen from the internal organs, because the liver collects blood and is the master of drainage, likes to be organized but not depressed; the spleen is the master of transportation and transformation, likes to be dry but not damp; if the joy and anger are uncontrollable and the worries and thoughts are uncontrollable, the liver will not surrender, forming qi depression, which will lead to blood depression and fire depression; if the diet is uncontrolled and the cold and temperature are uncomfortable, affecting the spleen and earth, the spleen will lose its healthy movement and lead to food depression, and even damp depression and phlegm depression will be formed. Therefore, the three depressions of qi, blood and fire are mostly blamed on the liver, while the three depressions of food, dampness and phlegm are mostly blamed on the spleen. According to the pathogenic characteristics of spleen and stomach diseases, we refer to the characteristics of the formula of Yue Ju Wan, which is an important formula idea to treat spleen and stomach diseases starting from the six depressions, so it can be considered that Yue Ju Wan is also a key formula for treating spleen and stomach diseases. Yue Ju Wan is the first formula of the opening chapter of the qi medicine, and the composition of the formula is composed of five equal parts of each of Cang Zhu, Xiang Xiang Xiang, Chuan Xiong, Shen Qu, and Gardenia, which can be used as a pill and a soup. Here, the author explores the medicinal characteristics of the five flavors of the formula found that, in addition to Cang Zhu, Shen Qu two flavors into the spleen and stomach meridian, the other three flavors are into the liver meridian, so it can be considered that Yue Ju Wan for the liver meridian formula, its solution to all the depression for the main solution to liver depression, also can be interpreted as the development of the liver meridian depressed gas, the liver is the main drainage, the smooth running of the whole body qi depends on the normal operation of the liver meridian qi and blood, so the liver and the spleen and stomach together coordinate the surrounding qi Therefore, it can be considered that regulating the liver means regulating the spleen, and treating the liver means treating the spleen, which also has the meaning of suppressing wood and replenishing earth. Therefore, we can see that today’s prescriptions for spleen and stomach diseases mostly contain medicine to regulate the liver. The spleen and stomach are the essence of the vital energy, nourishing the innate essence and serving as the hub for the movement of the essence. The spleen and the stomach are the epitome of each other, the stomach is the main receiver and the spleen is the main transporter, but both depend on the draining of the liver, which can also be interpreted as the draining function of the liver promotes the transport and transformation function of the spleen and stomach. The composition of the five flavors of Yue Ju Wan is determined by the fact that this formula enters the two meridians of liver and spleen, reflecting the close relationship between liver and spleen and stomach. As the saying goes, when we see the disease of the liver, we know that the liver transmits the spleen, so we should first strengthen the spleen. To treat the disease of the spleen and stomach, attention should be paid to regulating the liver, so that liver qi can be relaxed and the spleen and stomach can be transported and transformed. It can be concluded that the idea of the formula of Yue Ju Wan has a profound influence on the formula for treating spleen and stomach diseases. For example, the most common diseases of the spleen and stomach in Chinese medicine include stomach pain and fullness, which are equivalent to functional dyspepsia and chronic gastritis in Western medicine, and are mostly caused by disorders of living, diet and emotions, phlegm and gas congestion, and weakness of the spleen and stomach, resulting in loss of spleen health and movement. The liver is depressed, the seven emotions are stagnant, the qi is blocked, the liver wood is depressed but not stretched, so the chest and epigastric discomfort, stuffiness and fullness, the two dorsal swelling; liver qi is depressed and not allowed to reach, so the heart is irritable. If it is not cured for a long time, the chest and hypochondrium are full and the diet is little, the spleen and stomach are damaged, resulting in weakness of the spleen and stomach. The treatment is to de-stress the liver, regulate qi and eliminate stagnation, and at the same time strengthen the spleen. This formula is composed of Chuanxiong, Cangzhu, Xiangxiang, fried gardenia and Shenqu, and is a general treatment of Qi, blood, phlegm, fire, dampness and food, the actual focus is still on regulating Qi, because Qi moves blood, phlegm, fire, dampness and food are easy to dissipate; Poria, Semen, Atractylodes, Sharen and Chenpi strengthen the spleen and stomach. The combination of all the drugs to achieve the liver to relieve depression, qi and eliminate stagnation, as well as the effect of strengthening the spleen. According to Chinese medicine, the pathological basis of fatty liver is related to phlegm, dampness, stasis and stagnation, often because phlegm and dampness hinder the spleen and can eat but not transform, resulting in food stagnation and heat stagnation; stasis and stagnation affect the circulation of qi and blood, resulting in qi stagnation and blood stagnation, which cause the disease and are difficult to be resolved, resulting in the evidence of phlegm, dampness, heat, qi, blood and food stagnation. The Danxi Xinfa’s Yueju Wan is a famous formula for ruling the six depressions. Modern pharmacological research has confirmed its hepatoprotective effect, reducing the degree of hepatocyte degeneration and necrosis in liver injury; Shen Qu can eliminate food and remove turbidity, lowering lipids; Chuan Xiong moves Qi, activates blood stasis; Xiang Shen softens the liver and moves Qi; Gardenia clears heat and dampness, cools blood and detoxifies. The combination of all the drugs can help to relieve liver qi, spleen can transport phlegm, qi can move stasis and disperse, heat can be cleared and turbidity dispelled, which can not only relieve abdominal distension, weakness and discomfort in the liver area, but also reduce liver fat deposition, and at the same time improve liver function with definite efficacy. In particular, there are no deliberate lipid-lowering drugs in the formula, reflecting the advantages of evidence-based treatment. The causative factors of spleen and stomach diseases are poor diet, overwork, internal injury of emotion and will, external sensation of the six sexes, and physical weakness. Yueju Pill can relieve liver and depression, strengthen the spleen, resolve dampness and Qi, and activate blood to induce stagnation, covering the five major pathological mechanisms of spleen and stomach diseases. Although the dosage of the five herbs in the formula is equal, the dosage of a certain herb can be increased according to the weight of a certain part. For example, if the Qi stagnation is heavy, we can reuse Fragrant Herb, and if the Damp stagnation is heavy, we can reuse Atractylodes macrocephala. In addition, it is often added according to the weight of a certain part, such as dampness (heavy or pain around the body, when cold) plus Poria, Angelica, fire (head swelling, impatience, urinary redness, pulse count) plus Qing Dai, phlegm depression (moving wheezing, smooth pulse, chest tightness, greasy moss) plus Nanxing, half summer, Guaou, sea stone, blood depression (weakness of the limbs, can eat, chest and epigastric or tingling pain) plus Peach kernel, safflower, gas depression (chest and diaphragm swelling) plus Mu Xiang, betel nut, food depression (belching acid, abdominal distension, inability to eat) add malt, hawthorn, sand, hostage to cold (aggravated by cold, heat will be relieved) can add less dogwood. The modern pharmacological research of Yueju Pill shows that: Xiang has analgesic and anti-inflammatory effects; Chuanxiong has sedative and antispasmodic effects on pain; Chaihu has analgesic and sedative and anti-inflammatory effects. Yue Ju Wan is commonly used in clinical practice for the treatment of peptic ulcer, functional dyspepsia, irritable bowel syndrome, fatty liver, biliary pancreatitis and other digestive disorders, and is worthy of further study.