Symptoms of GERD are heartburn, reflux, chest pain, etc. The diagnosis is based mainly on symptoms + effective proton pump inhibitor treatment, etc. 1. Symptoms: Gastroesophageal reflux disease (GERD) is mainly caused by inflammatory lesions in the esophagus due to abnormalities in the structure and function of the anti-reflux barrier, a decrease in the clearance of the esophagus, and a decrease in the barrier function of the esophageal mucosa. Reflux and heartburn are typical symptoms of the disease. There are also symptoms such as dysphagia or retrosternal foreign body sensation and chronic cough. 2. Diagnostic basis: The diagnosis of GERD is mainly based on the typical symptoms of reflux and heartburn, coupled with the experimental treatment of oral proton pump inhibitors, such as omeprazole for about 7 to 14 days, the reflux and heartburn symptoms are significantly relieved, and can be initially diagnosed as gastroesophageal reflux disease. Patients with GERD need to consult a doctor promptly and follow the doctor’s instructions for active treatment.