Cranial defects are very common in life today, such as traumatic brain injury or craniosynostosis, which may be left after decompression of the bone flap. It is important to know that the skull is the hard shell of the brain, and once it is destroyed, all life activities in the skull will be affected, so it cannot be ignored. In neurosurgery, cranial defect is mainly dealt with by cranial repair surgery, which is an old classical surgical procedure with thousands of years of development history and mature technology, and the material of cranial repair is also constantly innovated to bring better surgical results. Currently, the main repair materials are titanium and polyether ether ketone peek, so which one is suitable for skull repair? Many patients want to know the answer, indeed there are still some differences between these two materials, for example, titanium material compared to those early materials although there are some progress, but there are also unsatisfactory places, it is not very good in histocompatibility, thermal insulation, etc., and there may be some postoperative complications and so on. In comparison, the new peek material is more ideal, it is a very safe polymer material, its performance is excellent, very close to the autologous cranial bone, the repair effect is also very good, become the new trend of doing skull repair surgery now. However, peek material is not yet popular in China, only a few hospitals can do it, we carry out here is earlier, the technology has been more mature. After continuous exploration and research, technical improvement and innovation, we have successfully carried out peek skull repair plastic surgery, and the post-operative effect is more natural and beautiful, which is highly praised.