Nimesulide and diclofenac sodium which is better varies from person to person, both belong to the non-steroidal anti-inflammatory drugs, need to choose according to the specific conditions. There are some differences between the two indications, but nimesulide is only used when at least one other non-steroidal anti-inflammatory drug treatment fails, if the patient does not have a contraindication to the use of diclofenac sodium can be preferred to diclofenac sodium. Nimesulide is used only if treatment with at least one other non-steroidal anti-inflammatory drug has failed, and can be used for the treatment of pain in chronic arthritis (e.g., osteoarthritis, etc.), pain after surgery and acute trauma, and the symptoms of primary dysmenorrhea. Diclofenac sodium is used for various chronic arthritis in the acute exacerbation or persistent symptoms of joint swelling and pain, all kinds of soft-tissue rheumatic pain such as shoulder pain, pain after surgery, trauma, strain, primary dysmenorrhea, dental pain, headache and so on. There is a certain difference between the two indications, in the patient does not have a contraindication to diclofenac sodium and the use of the drug is effective under the premise of diclofenac sodium should be preferred. Common adverse reactions after the use of the drug are stomach pain, nausea, vomiting, diarrhea and so on. It is contraindicated in people who are allergic to the drug, have active peptic ulcers or bleeding, and severe heart failure. Take care to use the smallest dose and the shortest period of time in order to ensure the efficacy of the drug, avoid combining it with other non-steroidal anti-inflammatory drugs. Drugs need to be used under the guidance of a physician, it is recommended that patients who need to take nimesulide or diclofenac sodium to the relevant departments of the regular hospital for treatment.