Enterochemistry refers to intestinal epithelial hyperplasia, which may pose a risk of malignancy in some patients, but does not occur in all patients. Regular review is needed to monitor the development of the lesion. Due to the stimulation of various factors, especially chronic inflammatory stimulation, patients’ gastric mucosal epithelium may be transformed into small or large intestinal mucosal epithelial tissue containing Paneth cells or cup cells, a process known as intestinal epithelialization. When these pathologic changes occur in patients, lesions such as chronic atrophic gastritis are most often seen. With long-term chronic irritation, malignant changes are possible. However, not all patients develop malignant changes. In the examination process, after the pathological changes of intestinal epithelial hyperplasia are found in the gastric mucosa, it is necessary to actively regulate the treatment of the underlying lesions, such as: chronic atrophic gastritis. Regular use of medication, while maintaining a good dietary habits, reduce the continuous stimulation of the gastric mucosa, reduce the progress of the development of lesions, reduce the risk of malignant lesions. If malignant changes are suspected, early diagnosis of the lesion should be made through pathological examination, and surgical treatment, radiotherapy and other therapeutic measures should be taken to stabilize the condition as much as possible.