There is no such thing as the most efficacious medication for degenerative arthritis. Effective drugs for treating degenerative arthritis include analgesics, glucocorticoids, hyaluronic acid, glucosamine, interleukin-1 inhibitors and so on. 1. Analgesics: non-steroidal anti-inflammatory painkillers, including diclofenac sodium, meloxicam, etc., are generally used, and have a better therapeutic effect on the inflammatory manifestations of arthritis, such as joint pain, swelling, effusion and limitation of movement. 2. Glucocorticoid: It is suitable for acute inflammatory manifestations and periarticular bursitis, tendonitis, etc. It can be injected locally into the joint cavity or lesion area, and should not be applied for a long time. 3. Hyaluronic acid: it is suitable for patients who have no effect on non-pharmacological treatment and painkillers, and the efficacy is poorer for patients with advanced stage, large amount of fluid in the joint cavity, and those who are over-obese. 4. Glucosamine: mainly used in early and middle stage arthritis patients. 5. Interleukin-1 inhibitor: Bisacodyl Ruin is a new interleukin-1 inhibitor, which can inhibit the inflammatory cascade reaction, with analgesic, anti-inflammatory and antipyretic effects, and can stimulate the formation of cartilage matrix material and promote the repair of cartilage. All the use of drugs should be under the guidance of medical professionals. It is recommended that patients with degenerative arthritis visit the rheumatology and immunology department in time and follow the doctor’s instructions for treatment.