It is mostly normal to have no reaction to the medication taken to treat ureteral stones. After long-term application of drugs, there is no reaction, or failed to discharge stones, is not a normal phenomenon. Treatment of ureteral stone drugs are mainly based on stone-dissolving drugs and stone-discharging drugs, such as common potassium citrate, tamsulosin, etc., which can play a role in dissolving stones, promote the role of discharging, and the treatment of stone disease often need long-term medication, in order to gradually dissolve the stones, discharged out of the body. After short-term use of the drug, under normal circumstances, patients will not have any reaction. There are also some patients who experience adverse reactions such as abdominal pain, dizziness, skin rash, etc. after using the drug, which should be handled by a doctor in a timely manner. It should be noted that, after long-term application of the drug, the patient does not have any reaction, including the stone did not successfully discharged, you should consider the possibility of improper use of the drug or the stone size is large, and need to take other measures in time for treatment. In the absence of any reaction after the use of drugs, can be timely to the urology department, should follow the doctor’s instructions to choose the appropriate medication and other treatment options.