Painkillers don’t work the day after tooth extraction and need to be treated according to the cause and symptoms. Post-extraction pain is often associated with irrational diet, inflammation and infection, nerve damage and other factors, according to the cause of the general treatment, drug treatment. 1. Irrational diet: Eating spicy and hot food in a short period of time may stimulate the tooth pulp and cause toothache. At present, you should eat a reasonable diet, and try to take light, nutritious, soft and easy to digest as the principle. You should also keep rinsing your mouth after eating to avoid food residue. 2. Inflammation and infection: If the improper care of the extracted tooth is infected with inflammation and produces an irritating reaction, it is easy to cause toothache. Oral metronidazole, tinidazole anti-inflammatory, reduce the inflammatory reaction, the pain is more serious, and then oral ibuprofen pain. 3. Nerve damage: nerve damage is more serious, simple oral painkillers are not effective, so the oral painkillers should be combined with vitamin B₁, vitamin B₆ nutritional nerve on the basis of oral painkillers. Toothache on the 2nd day after tooth extraction, it is recommended to observe and do a good job of oral cleaning and care, if the symptoms persist for a long time, you should consult a doctor in time, but the specific medication should be carried out in accordance with the doctor’s instructions.