It is advisable to go to the hospital for relevant examinations to clarify the specific disease: first, men with glansitis can have a red urethral orifice, accompanied by redness and swelling of other parts of the glans, and increased discharge, which requires pathogenic testing to confirm the diagnosis. The second, urethritis can also appear red urethral orifice, at the same time can be accompanied by frequent urination, urinary urgency, painful urination, or accompanied by urethral erosion and other symptoms, need to carry out routine urine examination to further confirm the diagnosis. Third, if there is excessive local friction, or excessive masturbation, etc., can lead to local redness of the urethra, usually not accompanied by urinary irritation symptoms or only with a slight stinging symptoms when urinating, after stopping the relevant stimulating factors reddening symptoms can be relieved. Fourth, women with urethral polyps, caruncles, combined with infection can appear the phenomenon of redness of the urethral orifice, while physical examination can be seen in the urethral orifice polyp-like bulge, the need for local topical drug treatment or surgical removal to deal with.