The 5-year survival rate after patients with advanced brain metastases from non-small cell lung cancer is about 5%, and the 5-year survival rate after advanced brain metastases from small cell lung cancer is about 3%. The specific survival time varies from person to person. Brain metastasis in advanced stage of lung cancer often suggests that the disease is deteriorating and the prognosis is poor. Patients can be treated with comprehensive therapy such as radiotherapy, chemotherapy and targeted therapy to inhibit tumor proliferation and metastasis, inhibit further deterioration of the tumor, improve the quality of life of patients and prolong the survival time of patients. Due to individual differences, there is no absolute most effective chemotherapeutic drugs and targeted drugs, we need to choose the most suitable drugs for ourselves under the guidance of doctors, and we suggest patients to relax their mindset and actively cooperate with doctors to receive standardized treatment to improve the prognosis of the disease and prolong the life of the patients.