There is no such thing as “what medicine works best” for hyperuricemia. According to the specific personal situation and condition of the choice of uric acid-lowering drugs and alkalinizing drugs. 1. Uric acid-lowering drugs: common types of uric acid-lowering drugs to inhibit uric acid production drugs and promote uric acid excretion drugs, inhibit uric acid production of drugs represented by the drug allopurinol and febuxostat, promote uric acid excretion of drugs represented by the drug phenylbromomalone and probenecid. 2. Alkalizing urine drugs: alkalizing urine drugs such as sodium bicarbonate and sodium citrate, potassium citrate and other citrate preparations are the main ones, which can play the role of alkalizing the patient’s urine and promoting the excretion of uric acid. The above drugs should be used under the guidance of a physician, it is recommended that the patient to the regular hospital endocrinology, rheumatology and immunology departments and other related departments for detailed consultation, standardized treatment in accordance with the doctor’s instructions, do not self-medication.