High total cholesterol, but not high triglycerides, should be treated with medication as appropriate on the basis of lifestyle improvement. High total cholesterol is closely related to inappropriate lifestyle and genetic factors, and its elevated level, especially LDL cholesterol, has an important link with the development of atherosclerotic diseases such as coronary heart disease and cerebral infarction. Therefore, for elevated total cholesterol, the first step is to improve the lifestyle, quit smoking and drinking, avoid oily and high salt diet, and maintain an appropriate frequency of aerobic exercise. In addition, if necessary, we need to control the total cholesterol by medication, statin such as atorvastatin, cholesterol absorption inhibitor ezetimibe, bile acid sequestering agent colesevelam, PCSK9 inhibitor iloyuzumab and so on. Specific medications should be prescribed by a doctor. It is recommended to consult a doctor to standardize the diagnosis and treatment if necessary.