Smallpox vaccination is not currently required. Through the efforts of peoples, smallpox has now been eradicated worldwide. Therefore, smallpox vaccination is no longer routinely required. Smallpox is a very serious viral infection. Smallpox patients are the main source of infection, and the smallpox virus is transmitted through droplets from the patient’s respiratory tract. Smallpox can be transmitted through droplets from the patient’s respiratory tract. Infection with smallpox results in a high fever, accompanied by body aches and pains, and can cause damage to many organs throughout the body. The disease progresses rapidly, and in the late stages of the disease, patients may become comatose. Smallpox has a high mortality rate, but there are no longer any epidemics of the virus and vaccination against smallpox is no longer necessary.