Epinephrine can be given subcutaneously, but for conditions such as rescue anaphylactic shock or hypotensive shock, the preferred method of administration is intramuscular injection, or epinephrine can be given subcutaneously. However, there are many issues to be aware of when giving subcutaneous injections, starting with the monitoring of the patient’s vital signs, such as heart rate, blood pressure, pulse rate, and arterial oxygen saturation. Because subcutaneous injection of epinephrine can induce cardiac arrhythmias and other conditions, it is important to use caution when administering the drug by subcutaneous injection. In addition, when giving subcutaneous epinephrine, the patient’s status should be evaluated, and intramuscular injection is recommended if the patient’s status is critical.