In order to avoid passing on a cleft lip to the next generation, it is necessary to screen for cancer-causing genes in one’s family line, as well as to perform a genealogical analysis to assess the risk of a fetus born with a cleft lip and palate. 1. Genetic screening. For syndromic cleft lip and palate, since it is a monogenic pattern of abnormality, genetic screening can be performed on the patient and his/her family to assess the risk of the birth of a cleft lip and palate fetus. 2. Genealogical analysis. For non-syndromic cleft lip and palate, genealogical analysis can be performed to assess the risk of birth of a fetus with cleft lip and palate by taking into account the characteristics of polygenic genetic disorders; the closer the relationship, the higher the morbidity rate, and inbreeding is strictly prohibited. At the same time to develop a good habit of life, no smoking and alcohol, strengthen nutrition, regular pregnancy examination, especially to pay attention to the screening of fetal anomalies during pregnancy, and find the problem as soon as possible to deal with.