Cholangitis is mainly characterized by middle and upper abdominal pain, chills and fever, jaundice, and should be distinguished from cholecystitis, pancreatitis and gallbladder cancer. 1. Cholecystitis: it is often a complication of gallbladder stones and can be divided into acute and chronic. Acute attack manifests as persistent pain in the right upper abdomen, radiating to the right shoulder or back, which may be accompanied by nausea and vomiting, fever. Chronic, mainly manifested as recurrent discomfort or abdominal pain in the right upper abdomen, mostly appeared after a full meal or eating greasy food, but usually the pain symptoms are mild or unnoticeable. 2. Pancreatitis: acute and chronic inflammatory lesions of the pancreatic tissue caused by a variety of factors. Acute abdominal pain is often the first symptom, can radiate to the lower back, obvious after eating, accompanied by nausea and vomiting, fever symptoms. Chronic cases often develop from acute cases. 3. Gallbladder cancer: It occurs mostly in middle-aged and old people, with no symptoms in early stage, and mainly manifests as epigastric pain, right upper abdominal mass and progressive jaundice in progressive stage, accompanied by abdominal distension, loss of appetite and hepatomegaly, etc. It cannot be diagnosed based on symptoms alone. Symptoms alone cannot confirm the diagnosis. If the above symptoms occur, it is recommended to consult a doctor in time to improve the relevant examination, clarify the condition with the help of a doctor, and carry out targeted treatment or therapy.