Mesenteric lymphadenitis in children does not heal on its own and needs to be treated according to the cause, usually with a 3-7 day course of antibiotic therapy. Children with mesenteric lymphadenitis usually develop secondary to viral infections. The immaturity of the immune system in children can lead to the spread of the virus through the lymph nodes and the development of lymphadenitis, with clinical manifestations such as fever, pain around the umbilicus, vomiting and, in some cases, constipation or diarrhea. The disease generally does not heal on its own and requires treatment of the primary disease, such as antiviral therapy, followed by antibiotic therapy suitable for children, such as third-generation cephalosporin, which can gradually improve and heal within 3-7 days. If no treatment is given, mesenteric lymphadenitis in children cannot be cured. In addition, since mesenteric lymphadenitis in children is usually related to their own resistance and toxin invasion, it is important to pay attention to a light diet, balanced nutrition, and appropriate protein intake to improve the patient’s own immunity during the illness.