When should antiangiogenic drugs be applied? Can they be used as soon as the patient is diagnosed? Antiangiogenic drugs should be used on top of effective radiotherapy, which serves as the icing on the cake rather than the silver lining. Chemotherapy has high toxicity and side effects, so it cannot be used indefinitely, whereas anti-angiogenic drugs are less toxic, so they can be used after chemotherapy is finished, which we call maintenance therapy. What tests should be done before applying anti-angiogenic drugs? Do I need to do genetic testing? Anti-angiogenic drugs do not currently target a clear tumor driver gene, so for their efficacy, only dynamic observation can be used. For example, if we see a decrease in the level of activated vascular endothelium in the blood, then the treatment is effective. The blood supply inside the tumor also needs to be monitored, as suppression of the blood supply to the tumor often predicts a good outcome.