Knuckle creases can be improved by applying hand cream. Generally speaking, knuckle crease is a physiological phenomenon, which is related to the mobility of the finger joints. Even if there are many creases, they usually do not affect normal life and do not require special treatment. If the folds increase due to dry skin or skin laxity, which affects aesthetics, they can be improved by massaging the fingers and applying hand creams externally. Surgical intervention is generally not recommended. If surgery is performed hastily, it may cause adhesions in the joints and affect normal activities. Please go to the hospital and consult a specialist for specific treatment under the guidance of a medical professional.