High total bile acid in pregnant women belongs to intrahepatic cholestasis in pregnancy, which requires monitoring of the condition, taking ursodeoxycholic acid and other medications, adjuvant therapy, and timely obstetric management. 1. Monitor the condition: those with severe itching and poor rest at night can be given sedative drugs such as diazepam, and attention should be paid to reviewing liver function once every one to two weeks to test the level of bile acids and understand the progress of the disease. Through the fetal heart monitor, ultrasonography and other means to monitor the fetal situation, the emergence of fetal movement and other conditions such as reduced timely access to medical care, the necessary obstetric treatment. 2. Medications: Ursodeoxycholic acid is the first line of treatment for this disease, acting as a choleretic substitute for toxic endogenous bile acids; S-adenosylmethionine can be used as a second line of treatment for this disease. 3. Adjuvant therapy: Dexamethasone is given in conjunction with obstetrics and neonatology when permitted to promote fetal lung maturation, and glycerite lotion and cetirizine can be used to provide moderate relief of pruritus when necessary. 4. Obstetrics treatment: Choose the appropriate time and way to terminate the pregnancy through the professional physician’s comprehensive assessment of the condition of the disease and the condition of the fetus. Pay attention to the use of drugs under the guidance of physicians.