Rh-negative blood is not a contraindication for kidney transplantation, and Rh-negative blood can also be used for kidney transplantation if there is a suitable donor. Before kidney transplantation, tissue matching between donor and recipient is required, and in principle, ABO blood type must be fully compatible before organ transplantation. However, due to the extremely low percentage of Rh-negative blood, kidney donors are very scarce, and there are cases of successful second kidney transplantation with Rh blood group incompatibility that have achieved better short-term clinical outcomes. However, the long-term clinical efficacy of Rh-negative transplantation needs to be followed up for further observation. The donor kidney should be thoroughly irrigated before transplantation, and attention should be paid to immune-inducing therapy before surgery and immunosuppression after surgery to reduce the incidence of rejection. Kidney transplantation is suitable for people with irreversible end-stage renal disease caused by various reasons, but if you have active hepatitis, active peptic ulcer disease and other diseases, you can’t undergo kidney transplantation before your condition is under control. It is recommended to go to regular hospitals for a comprehensive assessment of the condition, follow the doctor’s instructions and choose the appropriate treatment plan.