Let’s learn how to treat schistosomiasis cirrhosis today. We all know that the common causes of cirrhosis are mainly hepatitis cirrhosis, schistosomiasis cirrhosis, drug cirrhosis, biliary cirrhosis and so on. For schistosomal cirrhosis, we need to know that the site of portal vein obstruction is in front of the liver sinusoids, which is often referred to as pre-sinusoidal cirrhosis. The eggs of schistosomes can block the portal vein along with the portal blood flow, resulting in an increase in portal pressure, which leads to the proliferation of hepatocyte fibrous tissue, hardening of the liver, formation of liver pseudobullets, and as the blockage continues to worsen, it causes increased damage to hepatocytes, resulting in ischemia and atrophy of the liver due to lack of oxygen. Compared to hepatitis cirrhosis, schistosomiasis cirrhosis is often less hepatocellular damage and lower portal vein pressure elevation. Therefore, for mild schistosomiasis cirrhosis, as long as liver function transaminases, bilirubin, albumin and other indicators are normal, regular review is possible and no special treatment is needed. As the disease progresses, the indexes of liver function such as transaminase or bilirubin increase and albumin is low, so we can give liver protection, bile relief and albumin supplementation treatment. Once the patient bleeds with hypersplenism and upper gastrointestinal bleeding, surgery is often required to remove the spleen to interrupt portal pressure and improve the patient’s blood cell destruction.