White globule ratio refers to the ratio of albumin to globulin, the normal value is 1.5~2.5:1, with slight variations in different laboratories, and the decrease may be related to chronic liver diseases and extrahepatic diseases. 1. Chronic liver diseases: chronic hepatitis, cirrhosis and other liver diseases can reduce albumin and increase globulin, resulting in a low albumin-globulin ratio, if the ratio is lower than 1, it is suggestive of chronic hepatic damage, and a low albumin-globulin ratio is also suggestive of a poor prognosis of the disease. 2. Extra-hepatic diseases: nephrotic syndrome can lead to lower albumin, multiple myeloma, chronic inflammation can lead to lower globulin, and these non-hepatic diseases can also lead to low white globule ratio. If there is an abnormal white globule ratio test result, it is recommended to go to the hospital immediately, clarify the cause of the disease with the professional help of the doctor, and carry out targeted treatment or therapy.