Most of the hoarseness that occurs after chemotherapy can be improved. However, hoarseness cannot be recovered for direct damage to vocal cords caused by malignant tumor attack in pharyngeal area such as esophageal cancer. 1. Esophageal cancer: the treatment of esophageal cancer is mainly based on medication and surgical resection, during the surgical resection, part of the vocal cords and the surrounding nerves may be damaged, which may lead to permanent hoarseness or damage of vocal ability, and this kind of damage can not be recovered, which is an inevitable adverse symptom in cancer treatment. 2. Drug stimulation leading to hoarseness: for secondary hoarseness caused by chemotherapy drugs or local tumor compression, the use of antibiotics or oral laxative drugs to effectively promote the recovery of the mucous membrane of the pharynx and the vocal folds after the end of chemotherapy will gradually restore the voice to normal and will not affect the ability to produce sound. People who choose chemotherapy treatment can protect their throat during the use of drugs or increase the amount of water they drink during the course of the disease and treatment, which can effectively reduce the chances of hoarseness.