Patients presenting with chest tightness and the constant urge to sigh are more commonly seen clinically in patients with depression. Depressed patients can complain of chest tightness, panic, shortness of breath, alas and sighs mainly to the clinic, in the process, pay attention to check and detect the patient’s mood, thinking and other related symptoms. Patients with depression tend to have low mood, slow thinking, and diminished volitional activity, accompanied by low self-esteem, self-guilt, and self-blame. Patients often feel a lack of interest, pleasure, living is not interesting, so there are self-injurious thoughts or behavior. At this time, if it is said to affect the work, study and other social and occupational functions, can be diagnosed as depression, clinical treatment requires systematic antidepressant treatment, such as the application of paroxetine, sertraline, fluoxetine and other 5-hydroxytryptamine reuptake inhibitors, the whole course of the treatment effect is good. In addition, physical therapy can be used transcranial magnetic stimulation and electroconvulsive therapy to achieve good therapeutic effect.