Lymph nodes with clear borders are usually benign; if the lymph nodes are irregular in shape, have unclear borders and are hard, they are more likely to be malignant. In most cases, clear lymph node borders are benign, but it is necessary to take into account the shape and texture of the lymph nodes as well as the results of the final pathology to finalize the diagnosis. If the test result is inflammatory, it can be clarified whether it is caused by bacterial or viral infections, and anti-inflammatory or anti-viral drugs, such as cefprozil, ribavirin, etc.; if it is tuberculous lymphadenitis, it is necessary to take a combination of anti-tuberculosis drugs such as isoniazid, rifampicin, etc.; if it is a connective tissue disease, it is necessary to follow the doctor’s prescription to apply glucocorticosteroids (e.g., prednisolone), interferon, etc. treatment. For early malignant lymph nodes, there are also cases with clear boundaries. As the lesion involves the whole lymph node, it will result in irregular morphology, unclear boundaries and hardness of the lymph node. For lesions with clear borders, treatment should be carried out according to the results of the examination and the doctor’s opinion.