Li Moumou, female, 38 years old, underwent extensive total uterine + bilateral adnexal + pelvic lymph node dissection for “low-grade malignant endometrial mesenchymal sarcoma”, and developed edema in the left lower limb on the first day after the operation. DVT (deep vein thrombosis) refers to the abnormal clotting of blood in the deep vein to form a thrombus, which is most common in the lower extremity. It is more common in the left lower extremity, and the incidence is two to three times higher than that of the right side. It may be related to the fact that the left iliac vein has a longer path and the right iliac artery crosses it, so that the left iliac vein is compressed to different degrees. It is usually believed that: vascular wall damage, abnormal blood flow and blood composition changes are the 3 main factors that cause venous thrombosis. The causes of DVT triggered by malignant tumors are multiple, the most important of which is the release of procoagulant substances by malignant tumors that increase the activity of blood coagulation factors. In addition, surgical treatment of tumors and chemotherapy are also important factors leading to DVT, which may be related to the toxic effects of chemotherapeutic drugs on vascular endothelial cells, induction of hypercoagulable state, inhibition of fibrinolytic activity, tumor cell necrosis and venous cannulation. After lower limb venous thrombosis, especially trunk vein thrombosis, blood return to the affected limb is blocked. In the acute stage, the blood cannot return through the trunk vein, which causes the pressure in the vein to increase rapidly, and the water in the blood penetrates into the tissue through capillaries, causing the tissue to swell. And at the same time, the venous pressure increases, forcing the lateral branch veins to dilate and open, and the stagnant blood returns through the lateral branch veins, causing the swelling to gradually subside. Few lower extremity DVTs can lead to fatal pulmonary embolism, so treatment should include the lower extremity venous thrombosis itself and how to prevent the occurrence of pulmonary embolism, with surgical and non-surgical treatments in the acute phase and medication, surgery and compression therapy in the chronic phase. After the occurrence of DVT, nursing care is also crucial, including: psychological care, care of the affected limb, observation of bleeding, and prevention of crushing pneumonia and decubitus ulcer formation caused by long-term bed rest. How to prevent the formation of DVT (deep vein thrombosis) in lower limbs after gynecological malignancy surgery? 1. Before surgery, we should pay attention to inquire about personal and family history of venous thrombosis, and evaluate the tendency of thrombosis for the high-risk group with primary diseases before surgery: strictly grasp the indications for surgery: operate gently during surgery. 2.The most effective measure to prevent lower limb deep vein thrombosis is to get out of bed as early as possible. 3.Pay attention to whether the patient has color change, edema, superficial venous anger and deep pressure pain in the muscles of both lower limbs, and pay attention to the patient’s complaints. If the patient has heavy and distending sensation in the lower limbs after standing, the possibility of deep vein thrombosis in the lower limbs should be alerted. 4.Low-fat diet, high vitamin, high protein, rich in vitex diet. If necessary, use corkage, glycerin enema, etc. to avoid the increase of abdominal pressure caused by the difficulty of defecation, which affects the venous reflux. 5, postoperative patients should be careful with hemostatic drugs, postoperative attention to lower limb warmth, massage the patient’s lower limb flounder muscle and gastrocnemius muscle, and do ankle passive exercise, do not use too tight clothing to avoid blood stasis, to prevent venous thrombosis. If long-term infusion or intravenous drug administration is needed, avoid repeated punctures at the same site and the same vein, avoid lower limb infusion to prevent intravenous lining injury, and be more cautious especially when using irritating drugs.