The symptoms of headache before and during menstruation are considered to be migraine, which is mainly due to the sudden drop of estrogen in the body, causing cerebral vasoconstriction and diastole dysfunction, leading to headache in patients. It can be prevented by taking β-blockers, such as Betalucil 12.5mg orally twice a day, or calcium antagonists, such as nimodipine tablets or Xibirin capsules, 1 week before menstruation. When headache occurs during menstruation, the patient should take oral blood and brain granules, and also oral headache capsules. In addition, before and after the menstrual period should pay attention to avoid overwork, avoid eating spicy, stimulating food, and also avoid excessive mental tension, which will make the headache symptoms worse.