Frequent shaking in the corner of the eye area is usually due to either orbicularis oculi muscle spasm or facial muscle spasm. The orbicularis oculi is a circular muscle located under the skin of the eyelid that closes the eyelid when contracted, while the facial muscle is generally a muscle located inside the subcutaneous tissue of the facial skin and is important in the formation of facial expressions. Spasms of these two muscles can lead to twitching or shaking of the corners of the eyes, which is usually triggered by fatigue, colds, viral infections, etc., and needs to be diagnosed by ophthalmologists or neurologists in a timely manner. Treatment should pay attention to rest enough, can take oral methylcobalamin tablets, adenosylcobalamin tablets and other neurotrophic drugs to promote recovery.