Demyelinating disease occurs when the myelin sheaths of the cerebrospinal nerve axons are demyelinated. The diagnosis of demyelination is based on its clinical features, patients are children and young adults; acute onset, often with a history of cold, fever, infection, rash, vaccination, cold, childbirth or surgery in the month before the disease; positive oligoclonal zone band on cerebrospinal fluid examination; electrophysiology and mri may reveal some subclinical lesions in the brain; mri reveals abnormal signals in the white matter of the brain. Symptoms and signs of demyelinating myelitis disease is demyelinating myelitis, mostly acute multiple sclerosis (ms) spinal cord type. The clinical presentation is similar to that of post-infectious myelitis, but progresses more slowly, with the disease often peaking within 1-3 weeks. The antecedent infection may not be obvious, but is mostly incomplete transverse damage, showing weakness or paralysis of one or both lower limbs with numbness, insignificant level of sensory impairment or two planes, and urinary and bowel disorders.