Hand, foot and mouth disease (HFMD) can occur at any age, but is most prevalent in children under 3 years of age. HFMD is an acute infectious disease caused by enteroviruses. The infectious agents of this disease are patients and hidden infected persons, and it is mainly transmitted through the fecal-oral route. The population is generally susceptible, mostly in children under 5 years old, especially under 3 years old for the high incidence of age, most of the adults for hidden infection. Hand, foot and mouth disease is mainly manifested in the hands, feet, mouth and other parts of the skin and mucous membrane rash, herpes, ulcers, etc., the general symptoms are mild, about 1 week since the cure. In a few cases, the condition is severe, and meningitis, pulmonary edema, circulatory disorders and even life-threatening conditions may occur. Hand, foot and mouth disease is most common in infants and young children, but this disease should not be ignored at any age and should be treated promptly.