The need for anti-inflammatory drugs in children after a fever is determined by the nature of the child’s lesion. Firstly, if the fever is caused by a simple cold or a viral infection, anti-inflammatory drugs are not needed because they are ineffective in this case and may cause disorders of the intestinal flora and digestive discomfort in children. The second is the need to eat anti-inflammatory drugs, if the child’s fever is due to infection with bacteria or Mycoplasma pneumoniae, etc., these cases, we should promptly give the child cephalosporin or macrolide drugs, such as erythromycin, roxithromycin, etc.. Cephalosporins are mainly for fever caused by bacterial infections in children, while macrolide antibiotics are mainly for fever caused by Mycoplasma pneumoniae infections. Take anti-inflammatory drugs must be based on the specific condition to regulate the course of treatment as well as the number of times to regulate the treatment.