The preventive vaccine for HFMD is usually given in two doses, one month apart. It is chosen to be given intramuscularly in the deltoid muscle of the upper arm, mainly for infants and children over the age of half a year, and can provide a better preventive effect. The HFMD vaccine was marketed late, mainly for EV71 type of HFMD vaccine, which is mainly for preventing EV71 type of infection, as this type of virus infection can easily cause severe cases. HFMD is an acute infectious disease caused by a group of enterovirus infections, with a high incidence in children, especially preschoolers, mainly manifesting as herpes on the hands, feet, mouth and buttocks. The prognosis of most HFMD is relatively good, but there are always severe cases in the clinic, which can lead to serious complications of the circulatory and neurological systems, and even a certain degree of lethality, so the prevention of HFMD should be strengthened.