Foreskin cleft swelling and pain is considered to be caused by trauma, glans penis, prepuce and other factors, different causes, different medication, you can use povidone-iodine, clotrimazole cream, dinexed cream and so on. 1. Trauma: If the foreskin is injured by the zipper of the pants, it can cause swelling and pain of the foreskin fissure. Patients can use local iodophor to sterilize, and if secondary infection occurs, erythromycin ointment can be applied for treatment. 2. glans phimosis: an inflammatory disease caused by pathogen infection, external stimulation and other factors, the patient’s glans phimosis will appear red, swollen, burning pain and other phenomena, serious ulcers, fissures, and even bleeding. Patients can use miconazole cream, clotrimazole cream, etc. to control the condition, if due to allergic or autoimmune diseases caused by glans, glucocorticoid cream, such as betamethasone cream, etc. to relieve symptoms. 3. Phimosis: Phimosis patients due to the foreskin can not be upturned, the glans can not be exposed, so that the pathogenic microorganisms in the foreskin glans reproduced, thus stimulating the foreskin triggered inflammation, the appearance of the foreskin fissure, swelling and pain and other phenomena. Patients with congenital prepuce can basically heal themselves by the age of 3~4 years old; secondary prepuce usually cannot heal itself, and steroid ointment, such as Dinocap, can be used locally to relieve the narrowing of the opening of the foreskin; if necessary, surgical treatments, such as circumcision and phimosis, can be chosen after the doctor’s evaluation. It is recommended that patients seek timely medical attention to clarify the cause of the disease and follow the doctor’s instructions to avoid blind use of medication.