Frequently waking up between one and three o’clock may be related to environmental factors, mental and psychological factors, disease factors and so on. 1. Environmental factors: such as noise in the sleeping environment, excessive humidity and dryness of the air, etc., may affect the quality of sleep and make people wake up between one and three o’clock. It is recommended to choose a suitable sleeping environment to help improve the quality of sleep. 2. Mental and psychological factors: for example, unpleasant things happened in life, excessive mental stress leading to emotional disturbance, tension, anxiety, depression, etc., which may also lead to waking up between 1:00 and 3:00, or even inability to fall asleep after waking up. 3. Disease factors: such as cardiovascular and cerebrovascular disease patients during sleep, the brain is prone to insufficient blood supply, headache and dizziness and other symptoms, resulting in the body due to discomfort, was suddenly awakened. Patients with diabetes mellitus, will be due to elevated blood sugar, causing osmotic diuresis, resulting in frequent urination, appearing to wake up at one to three o’clock. In addition to the above, there are other conditions that may lead to the emergence of one to three waking up, if you improve the sleep environment, the symptoms did not improve, it is recommended to go to the hospital for examination, follow the doctor’s instructions in a timely manner for targeted treatment, so as not to delay the course of the disease.