“With the liberalization of two children in the 13th Five-Year Plan, more women of childbearing age with chronic hepatitis B will be considering their fertility plans, and some have too much confusion about safe motherhood. I am 29 years old, married and childless. I’ve known about “triple III” for 6 years, and for the last 4 years, my aminotransferases have not been normal, 100 U/L or less. Intermittently in the county hospital to prescribe liver protection and enzyme-lowering drugs, the effect is not good, once the drug will rise. At the beginning of July this year, transaminase 195 U/L, liver hardness 12.3 kPa, the virus is 8 times (unspecified unit), go to the provincial hospital to prescribe enzyme-lowering drugs, after eating for 3 months, liver function is now normal, alpha-fetoprotein more than the normal value of 0.77 ng / ml, but the hardness of the liver to 14.3 kPa, ultrasound suggests that liver parenchymal echogenicity thickening, the virus is reduced to 5 times (unspecified unit). . I haven’t taken antiviral medication yet, and my doctor called me to stop the hepatoprotective medication for observation to prepare for pregnancy, will the whole process of using antiviral medication have any effect on the child? I want to start pregnancy next month, I am 29 years old and I am afraid that my liver hardness will continue to rise. In my case, can I not take any medication now, prepare for pregnancy next month, and start antiviral treatment by the 28th week of pregnancy? Case Study] Is it appropriate to delay antiviral treatment for a long time in order to prepare for childbirth? I have seen many highly educated women of childbearing age with hepatitis who are still using enzyme-lowering drugs or herbal medicines to reduce aminotransferases and delay antiviral treatment. Everyone knows that pneumonia must be treated with antibacterial drugs, antipyretics can only reduce body temperature; similarly, chronic hepatitis B enzyme-lowering drugs can not reduce the virus, control inflammation is extremely unstable, antiviral therapy is no substitute! Many current patients with cirrhosis are thus delayed. Why is such a common sense issue not cognizant in women of childbearing age who have a higher level of knowledge? There is a 30-something-year-old primigravida woman, born with a liver only slightly larger than half, and unfortunately suffered from “triple sun” transaminase high compensated cirrhosis, do not listen to the advice of the local doctors, had to give birth to this child, came all the way from Heilongjiang to Guangzhou to ask for help, I was touched by her this kind of persistent motherhood complex. I was touched by her persistence in motherhood. I analyzed her liver cells, which were already insufficient in number and damaged by active inflammation, and although the increase in liver burden due to pregnancy was limited, it was difficult for her to support the delivery of the baby, and she might have a hemorrhage during labor, or she might have an acute liver failure if her condition worsened after delivery. Taking tenofovir antiviral therapy can rapidly control inflammation and repair damaged liver cells; if she is willing to come to our hospital for delivery, I can do my best to protect her after delivery. She agreed to come to Guangzhou at the end of her pregnancy, but when she went home, she was concerned that tenofovir was not safe for the fetus, and asked a famous Chinese medicine practitioner to treat her aminotransferases to reduce them, but the virus was still high, so I was angry and helpless. Obstetrics rescue hemorrhage, only at this time to take tenofovir, acute exacerbation of the condition, finally did not occur liver failure. I hope her child grows up to be intellectually and physically sound. Strong mother’s love can also make people confused! The phrase “all medicines are poisonous” refers exclusively to modern medicines that have been tested on animals and rigorously clinically proven, but not to Chinese medicines that have not been clinically tested! What are the risks of having children in patients with chronic hepatitis who may be fibrotic? Pregnancy does not increase the burden on the liver; childbirth does. Postpartum hepatitis occurs in about 40% of chronic carriers, and hepatitis with significant fibrosis is at risk of acute exacerbation after delivery. Why? Paternal sperm and maternal egg, developing into a fetus, half of the genes come from the father. We all know: transplantation of other people’s kidneys are necessary to use immunosuppressive drugs to fight rejection. Have you ever wondered how the half of the fetus in the womb of a pregnant woman, which was transplanted by the father, can grow up without being rejected (miscarried)? Because of billions of years of evolution, the pregnancy is also immunosuppressed and may increase the level of the virus by a factor of 1, simply because the pregnant woman’s increased blood volume is diluted. The fetus is delivered, immunity can rebound significantly, and about 40% of mothers can develop labor hepatitis within 6 months, and patients with cirrhosis may have an acute exacerbation of their condition. Tenofovir is very potent, rapidly removes replicating viruses from the bloodstream, inflammatory destruction can be restored, and the remaining cirrhosis is compensated for (there is also a congenital deficiency in the number of hepatocytes in the above patients), which will always be much safer.