As early as in the Yellow Emperor’s Classic of Internal Medicine, traditional Chinese medicine has proposed that insufficient endowment, weakness of the five organs, mental stimulation, emotional and mental disorders, over-eating fat and sweet, and obesity have a close relationship with the occurrence of thirst disease. Since then, generations of physicians have continued to play on this basis, so that the theory of the etiology of diabetes mellitus has become more and more perfect and enriched, now the comprehensive literature on the causes of diabetes mellitus is outlined below. 1. Insufficient endowment and weakness of the five viscera The “Spiritual Pivot” says: “If the five viscera are soft and weak, they are good at disease elimination”. The Spiritual Pivot? The “Organ” chapter also said: “The heart is brittle is good at disease elimination and fever, the lung is brittle liver is brittle spleen is brittle kidney is brittle, then all good at disease elimination and thirst is easy to hurt.” Here it is discussed that the congenital deficiency of endowment, the deficiency of the five organs, the deficiency of vital essence, the weakness of qi and blood, and finally the deficiency of essence and liquid exhaustion and the development of thirst. This is consistent with the modern medical belief that diabetes has a genetic predisposition. Among the weaknesses of the five organs, ancient and modern medical practitioners have emphasized the importance of kidney deficiency in the development of achalasia. The “Secret Guide to the Wai Tai” points out that “those who are thirsty, originally started this is due to kidney deficiency.” In the Qing dynasty, the Chinese medicine practitioners have emphasized the importance of kidney deficiency in the development of thirst. Chen Shiduo also said: “The evidence of thirst, although divided into the upper and lower, and kidney deficiency to thirst, there is no difference. Song? Chen Wuzhe in the “three causes of extreme a disease evidence formula” pointed out: “there are three diseases, said thirst, thirst, thirst, thirst, kidney. The kidneys are the kidneys, when the strong, do not take care of themselves, fast love and indulgence, extremely intent on the room, long kidney failure, take more Dan Shi.” Sheng Ji Zong Lu” to “excessive labor, essence and blood deficiency” as an important cause of “kidney elimination”. This means that the ancients believed that kidney deficiency was the direct cause of thirst disorders. Modern research proves that kidney supplementation can not only improve the symptoms of kidney deficiency, but also stimulate the secretion of insulin, partially restore the function of pancreatic beta cells, regulate the body’s glucose metabolism, lower blood sugar, and enhance immune function and improve the role of microcirculation. 2, diet is not moderate Chinese medicine believes that the inordinate diet, injury to the spleen and stomach, spleen loss of health, water and grain fluids do not return to the correct transformation, but straight down into urine, but also the cause of thirst or drinking inordinate, fire and heat accumulation, resulting in the fierce heat of the three jiao, the five organs dry, fluid injury withered, the development of thirst. Su Wen? Treatise on Strange Diseases. The emperor said: “What is the name of the disease of those who have a sweet mouth? How do you get it?” Qibo said: “This is the overflow of the five qi, named spleen disease. The five flavors are hidden in the stomach, and the spleen moves its essence, and the fluids are in the spleen, so the mouth is sweet. This person must have eaten a lot of sweet and fat, fat, making internal heat, sweet, making the middle full, so its gas overflowed, turned into thirst”. Su Wen. The general assessment of the theory of deficiency: “disease… fat people, then the disease of sorghum”. This is the world’s earliest discussion of obesity and excessive sweetness of diet leading to diabetes, and has been recorded in important medical books since then. For example, the “Prepared Emergency Thousand Gold Medicine Formula” says: “Where the accumulation of a long time drinking wine, there is no thirst”, Ming? Jing Yue Quan Shu” contains “thirst disease, the origin of its disease, are fat and sweet changes, …… are rich and noble people sick and the poor few also.” This is consistent with the modern medical obesity is an important environmental factor leading to diabetes. 3, the mood is too extreme long-term excessive mental stimulation, emotional discomfort, or depression and anger injury liver, liver loss of drainage, gas depression into fire, burning the lung and stomach yin and fluid, burning the kidney yin; or excessive thinking, heart gas depression, depression and fire, heart fire is hyperactive, loss of heart and spleen essence and blood, burning the stomach and kidney yin, can lead to the occurrence of thirst disease. The Ling Shu said that “anger is the Qi upward rebellion, the chest accumulation, blood and gas rebellious stay, C skin filled muscle, blood vessels do not work, and turn to heat, heat is eliminated skin, so for elimination disease”. The Six Books of the River” also has a cloud “consume the spirit of chaos, too contrary to its degree …… Yang Qi Hum and dryness and heat depression is also the result of”. The “clinical guide to medical cases” pointed out: “the state of mind is sad and depressed, internal fire spontaneous combustion, is the great disease of thirst”. Modern scientific research has confirmed that: excessive emotions will cause an increase in the secretion of stress hormone growth hormone, norepinephrine, pancreatic glucagon, adrenaline, adrenocorticotropic hormone and other hormones that antagonize insulin, and these hormones can counteract the action of insulin and raise blood sugar. The long-term release of a large number of these hormones can easily cause endocrine metabolic disorders, causing diabetes 4, six external sensations, poisonous evil invasion Chinese medicine believes that six external sensations, dry fire, wind and heat poisonous evil internal invasion of the pancreas (pancreas), the side and the internal organs, dryness and injury, can also occur thirst disease. For example, in Qin Jingming’s “The Causes of Disease”, he classifies thirst disorders according to their causes into three disorders of external sensation (three disorders of dryness and fire and three disorders of dampness and fire) and three disorders of internal injury (three disorders of accumulated heat and three disorders of essence deficiency). The three externally induced diseases are the three externally induced diseases of thirst caused by the six toxic influences. Modern medicine also believes that the onset of IDDM and certain viral infections such as coxsackie B4 virus, encephalitis virus, myocarditis virus, mumps virus, rubella virus, EBV, etc. have a significant relationship. 5, abuse of warm tonic In ancient China, since the Sui and Tang dynasties, there are often people in order to aphrodisiac indulgence or health to prolong life and take the elixir made of ore-based drugs resulting in dryness and internal heat, depletion of yin and fluid and thirst disease. In many ancient medical texts, there are records of thirsty people taking elixirs. For example, Sui? The Source of Diseases contains the cloud: “The internal consumption of disease …… by less serving five stones, stone heat knotted in the kidneys also, the heat made.” According to the records, Emperor Yang’s diabetes was caused by taking aphrodisiac pills. Modern medicine believes that there are indeed some chemical poisons such as tetracycline, streptozotocin, pyrimethoprim, and certain drugs such as oral steroidal contraceptives, adrenal corticosteroids can lead to the occurrence of diabetes. It can be seen that in ancient China, the cause of diabetes has been clearly documented.